Compound of silver glycocholate readily soluble in water and process of making same.



7 late are introduced by portions, while-stir- UNITED STATES PATENT crates.

KARL KAUTZSCH, or nocHsr-oNmHE-MAm, GERMANY, ASSIGNOR T0 maswamm vomvr. MEISTER LUCIUS & sanmne, or HooHsr-oN-rrrnmm, GERMANY, A con- PORATION OF GERMANY.

COMPOUND SILVER GLYCOGHOLATE READILY SOLUBLE IN 'WATER AND PRC (JESS O1? MAKING SAME.

No Drawing.

To all whom it may concern: I,

Be it known that I, KARL KAUTzsc-H, Ph. D., chemist, a citizen of the Empire of Germany, residing at Hochst-on-the-Main,

Germany, have invented certain new and .meth'ylenetetramin to act upon silver glycocholate and preparing, if required, a solid product for instance by evaporation. at a low temperature. The product thus ob tained is a colorless or only slightly-colored powder, readily soluble in water, in hot alcohol of 90 per cent. strength and in methyl alcohol, almost insoluble in ligroin; when treating an aqueous solution of the product with hydrochloric acid hexamethylene-tetramin is separated as;a hydrochlorid with simultaneous formation of a precipitate of silver chlorid mixed with. diflicultly-soluble glycocholic acid. The new product is of an excellent therapeutic efliciency in the treatment of gonorrheal diseases. It ofiers, apart from its useful property of rendering the silver glycocholate soluble in water,.t he further advantage that it contains the therapeutically active hexamethylenetetramin.

The following examples illustrate my invention, the parts being by weight:

Example I: 100 parts of silver glycochoring or shaking, into a concentrated aqueous solution containing 196 parts of h xamethylenetetramin, whereupon the silver salt becomes dissolved. The solution thus obtained is carefully evaporated preferably in a vacuum at a low temperature and, if possible, in the-dark. The heXamethylcne-silver glycocholate left is readily soluble in water, in hot alcohol of 90 per cent. strength and in methyl alcohol, almost insoluble in ligroin. The product contains 6.3 per cent. of Ag. The proportions of t e silver glycocholate and thehexamethylenetetramin need not be exactly e same as those above indicated in order to obtain a product which is soluble in water.

Specification of Letters Patent.

Patented Nov. 15:3, 1915.

Application filed January 30, 1915. Serial No. 5,214.

Example II: 20 parts of glycocholic acid and then is added in the dark by portions, while stirring and gently heating, a quantity of moist silver oxid corresponding to a little more than 4.7 parts of silver, whereby the silver oXid is gradually converted. The excess of silver oxid is filtered off, to the solution are then added in small portions, also in the dark while stirring, 39.2 parts of hexamethylenetetramin and the resulting solution, if required after having been'treated with animal charcoal, is evaporated to dryness at a low temperature and in the dark. A much smaller quantity. of spirit than above indicated, indeed only about half of the aforementioned quantity, is required if already during the introduction of the silver oxid there is also added by portions hexamethylene-tetramin,starting with about half of the required total quantity of it, the remaining quantity being added to the warm filtered solution; otherwise the operation. is carried out as above indicated.

Having now described my invention, what I claim is;

1. The process of preparing a compound I ous formation of a precipitate of silver chlorid mixed with difficultly-soluble glycocholic acid.

In testimony whereof I aflix my signature in presence of'two witnesses.

KARL KAUTZSGH.

Witnesses JEAN GRUND, CARL GRUND. 

